Our lab is mainly interested in mechanisms and interplay of transcription, epigenetics, and chromatin structure as well as their impact on cell biology in health and disease.
Using combinations of genome-wide assays and biochemistry to study how transcription factors select their binding sites in the context of nuclear chromatin.
Studying the establishiment & function of epigenetic marks in normal myeloid development and leukemia using genome-wide technologies and functional approaches.
Understanding the role of cohesin and its mutations in hematopoiesis & leukemia using advanced genome-wide approaches to map the genome in three dimensions.
Leveraging genome-wide technologies and bioinformatics analysis to understand transcriptional networks controlling the therapeutic efficacy of regulatory T cells.
Applying mouse models and genetic engineering to understand the impact of DNA methylation on metastatic progression.
Using genetic and epigentic screens to identify mechanisms behind interindividual epigenetic variation.
With our expertise in NGS technologies and data analysis, we are involved in various collaborative efforts and consortia on cancer, immunology and epigenetics.
Without the funding from the following agencies and foundations, our research would not be possible!
Michael Rehli • Dept. Internal Medicine III • University Hospital
F.-J.-Strauss Allee 11 • 93053 Regensburg • Germany
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