Mononuclear Phagocyte Biology
Epigenetics of Cell Differentiation

Journal Club

Zellbiologisches Literaturseminar für Doktoranden (Vst. Nr. 56265)
Thursday 9:00 am, biweekly
in D53.320 (LIT seminar room) and via Zoom

next date: 19.05.2022
Targeting TREM2 on tumor-associated macrophages enhances immunotherapy

Binnewies et al.

Cell Reports 37, 109844 October 19, 2021 a 2021 Pionyr Immunotherapeutics.

Binnewies et al. show that TREM2- expressing tumor-associated macrophages (TAMs) are critical mediators of immune suppression in the tumor microenvironment (TME) and correlate with T cell exhaustion in human cancer. Effector-enhanced anti-TREM2 antibody treatment alters the abundance and phenotype of TAMs in the TME and sensitizes the response to anti-PD-1 therapy.

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05.05.22 AG Poeck
19.05.22 AG Pukrop (Zoom only!)
02.06.22 AG Rehli
23.06.22 AG Kreutz
07.07.22 AG Hoffmann

last updated: 12.05.2022

Michael Rehli • Dept. Internal Medicine III • University Hospital
F.-J.-Strauss Allee 11 • 93053 Regensburg • Germany

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