AG Rehli

Gebhard C, Mulet-Lazaro R, Glatz D, Schwarzfischer-Pfeilschifter L, Schirmacher P, Gaedcke J, Weichert W, Reuschel E, Dietmaier W, Rehli M. (2021). Aberrant DNA methylation patterns in microsatellite stable human colorectal cancers define a new marker panel for the CpG island methylator phenotype. Int J Cancer in press [Open Access Article]

Mendes K, Schmidhofer S, Minderjahn J, Glatz D, Kiesewetter C, Raithel J, Wimmer J, Gebhard C, Rehli M. (2021). The epigenetic pioneer EGR2 initiates DNA demethylation in differentiating monocytes at both stable and transient binding sites. Nat Commun 12:1556 [Open Access Article]

Minderjahn J, Schmidt A, Fuchs A, Schill R, Raithel J, Babina M, Schmidl C, Gebhard C, Schmidhofer S, Mendes K, Ratermann A, Glatz D, Nuetzel M, Edinger M, Hoffman P, Spang R, Laengst G, Imhof A & Rehli M. (2020). Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1. Nat Commun 11:402 [Open Access Article]

Gebhard C, Glatz D, Schwarzfischer L, Wimmer J, Stasik S, Nuetzel M, Heudobler D, Andreesen R, Ehninger G, Thiede C, Rehli M. (2019). Profiling of aberrant DNA methylation in acute myeloid leukemia reveals subclasses of CG-rich regions with epigenetic or genetic association. Leukemia 33:26-36 [Abstract]

de Rie D, Abugessaisa I, Alam T, Arner E, Arner P, Ashoor H, Åström G, Babina M, Bertin N, Burroughs AM, Carlisle AJ, Daub CO, Detmar M, Deviatiiarov R, Fort A, Gebhard C, Goldowitz D, Guhl S, Ha TJ, Harshbarger J, Hasegawa A, Hashimoto K, Herlyn M, Heutink P, Hitchens KJ, Hon CC, Huang E, Ishizu Y, Kai C, Kasukawa T, Klinken P, Lassmann T, Lecellier CH, Lee W, Lizio M, Makeev V, Mathelier A, Medvedeva YA, Mejhert N, Mungall CJ, Noma S, Ohshima M, Okada-Hatakeyama M, Persson H, Rizzu P, Roudnicky F, Sætrom P, Sato H, Severin J, Shin JW, Swoboda RK, Tarui H, Toyoda H, Vitting-Seerup K, Winteringham L, Yamaguchi Y, Yasuzawa K, Yoneda M, Yumoto N, Zabierowski S, Zhang PG, Wells CA, Summers KM, Kawaji H, Sandelin A, Rehli M; FANTOM Consortium, Hayashizaki Y, Carninci P, Forrest ARR, de Hoon MJL. (2017). An integrated expression atlas of miRNAs and their promoters in human and mouse. Nat Biotechnol. 35:872-878 [Abstract]

Hume DA, Summers KM, Rehli M. (2016). Transcriptional Regulation and Macrophage Differentiation. Microbiol Spectr. 4 [Abstract]

Joshi A, Pooley C, Freeman T, Lennartsson A, Babina M, Schmidl C, Geijtenbeek T, Michoel T, Severin J, Itoh M, Lassmann T, Kawaji H, Hayashizaki Y, Carninci P, Forrest A, Rehli M, and Hume DA. (2015). Transcription factor, promoter and enhancer utilisation in human myeloid cells. J. Leuk. Biol. 97:985-995 [Abstract]

Schmidl C, Hansmann L, Lassmann T, Balwierz PJ, Kawaji H, Itoh M, Kawai J, Nagao-Sato S, Suzuki H, Andreesen R, Hayashizaki Y, Forrest ARR, Carninci P, Hoffmann P, Edinger M, Rehli M for the FANTOM consortium. (2014). The enhancer and promoter landscape of human regulatory and conventional T cell subpopulations. Blood 123:e68-e78 [Abstract]

Schmidl C, Renner K, Peter K, Eder R, Lassmann T, Balwierz PJ, Itoh M, Nagao-Sato S, Kawaji H, Carninci P, Suzuki H, Hayashizaki Y, Andreesen R, Hume DA, Hoffmann P, Forrest ARR, Kreutz MP, Edinger M, Rehli M. for the FANTOM consortium. (2014). Transcription and enhancer profiling in human monocyte subsets. Blood 123:e90-e99 [Abstract]

The FANTOM Consortium. (2014). A promoter level mammalian expression atlas. Nature 507, 462–470 [Abstract] (joint first authors: Forrest ARR, Kawaji H, Rehli M, Baillie JK)

Andersson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Ntini E, Arner E, Valen E, Li K, Schwarzfischer L, Glatz D, Raithel J, Lilje B, Rapin N, Bagger FO, Jørgensen M, Andersen PR, Bertin N, Rackham O, Burroughs AM, Baillie JK, Ishizu Y, Shimizu Y, Furuhata E, Maeda S, Negishi Y, Mungall CJ, Meehan TF, Lassmann T, Itoh M, Kawaji H, Kondo N, Kawai J, Lennartsson A, Daub CO, Heutink P, Hume DA, Jensen TH, Suzuki H, Hayashizaki, Y, Müller, F, Forrest ARR, Carninci P, Rehli M, Sandelin A. (2014). An atlas of active enhancers across human cell types and tissues. Nature 507, 455–461 [Abstract] (joint first authors: Andersson R, Gebhard C; corresponding authors: Forrest ARR, Carninci P, Rehli M, Sandelin A.)

Klug M, Schmidhofer S, Gebhard C, Andreesen R, Rehli M. (2013) 5-Hydroxymethylcytosine is an essential intermediate of active DNA demethylation processes in primary human monocytes. Genome Biol. 14, R46. [Open Access Article]

Pham TH, Minderjahn J, Schmidl C, Hoffmeister H, Schmidhofer S, Chen W, Längst G, Benner C, Rehli, M (2013) Mechanisms of in-vivo binding site selection of the hematopoietic master transcription factor PU.1 Nucleic Acids Res. 41:6391-6402. [Open Access Article]

Pham TH, Benner C, Lichtinger M, Schwarzfischer L, Hu Y, Andreesen R, Chen W, Rehli M. (2012). Dynamic epigenetic enhancer signatures reveal key transcription factors associated with monocytic differentiation states. Blood 119, e161-71 [Abstract]

Hansmann L, Schmidl C, Kett J, Steger L, Andreesen R, Hoffmann P, Rehli M, Edinger M. (2012). Dominant Th2 differentiation of human regulatory T cells upon loss of FOXP3 expression. J Immunol. 188, 1275-1282. [Abstract]

Schmidl C, Hansmann L, Andreesen, R, Edinger M, Hoffmann P, Rehli M. (2011). Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naïve Treg cells. Eur J Immunol. 41, 1491-98. [Abstract]

El Chartouni C, Rehli M. (2010). Comprehensive analysis of TLR4-induced transcriptional responses in interleukin 4-primed mouse macrophages. Immunobiology. 215, 780-787. [Abstract]

El Chartouni C, Schwarzfischer L, Rehli M. (2010). Interleukin-4 induced interferon regulatory factor (Irf) 4 participates in the regulation of alternative macrophage priming. Immunobiology. 215, 821-825. [Abstract]

Klug M, Heinz S, Gebhard C, Schwarzfischer L, Krause SW, Andreesen R, Rehli M. (2010). Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels. Genome Biol. 11, R63. [Open Access Article] Research Highlight in Nature 466, 163.

Gebhard C., Benner C., Ehrich M., Schwarzfischer L., Schilling E., Klug M., Dietmaier W., Thiede C., Holler E., Andreesen R., Rehli M. (2010). General transcription factor binding at CpG islands in normal cells correlates with resistance to de novo DNA methylation in cancer cells. Cancer Res. 70, 1398-1407. [Abstract]

Schilling E, El Chartouni C, Rehli M. (2009). Allele-specific DNA methylation in mouse strains is mainly determined by cis-acting sequences. Genome Res. 19, 2028-35 [Abstract]

Schmidl C, Klug M, Boeld T, Andreesen R, Hoffmann P, Edinger M, Rehli M. (2009). Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. Genome Res. 19, 1165-74. [Abstract]

Korb J, Weil T, Hoffmann K, Foster KR, Rehli M. (2009). A gene necessary for reproductive suppression of termites. Science 324, 758 [Abstract]

The FANTOM Consortium. (2009). The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genetics 41, 553-62. [Abstract]

Lichtinger M, Ingram R, Hornef M, Bonifer C, Rehli M. (2007). Transcription factor PU.1 controls transcription start site positioning and alternative TLR4 promoter usage. J. Biol. Chem. 282, 26874-83. [Abstract]

Schilling E, Rehli M. (2007) Global, comparative analysis of tissue-specific promoter CpG methylation. Genomics 90, 314-23. [Abstract]

Pham TH, Langmann S, Schwarzfischer L, El Chartouni C, Lichtinger M, Klug M, Krause SW, Rehli M. (2007). CCAAT enhancer-binding protein beta regulates constitutive gene expression during late stages of monocyte to macrophage differentiation. J Biol Chem. 282, 21924-33. [Abstract]