Mononuclear Phagocyte Biology &
Epigenetics of Cell Differentiation
Epigenetics of Cell Differentiation
Although every cell in the human body shares an identical genome, most genes are only activated in certain cell types, at specific developmental stages, or upon stimulation. To organize and manage genetic information and to enable cellular specification, nature has evolved sophisticated mechanisms that facilitate the tightly controlled, accurate activation of genes.
Our laboratory is interested in the processes that orchestrate cell type-specific gene regulation during cellular differentiation. We study the interplay between transcription factors and epigenetic mechanisms (in particular DNA methylation) in regulating hematopoietic lineage specification and leukemia development.
Our collaborative study on the fate, phenotype, and clinical efficacy of ex vivo expanded and co-transplanted donor regulatory T cells got published in Nature Communications.
Claudia's follow-up project in the DFG SPP2202 "Spatial Genome Architecture in Development and Disease" received funding.
Our group is running the Sequencing Core at the LIT. We offer a wide range of services for the local scientific community. This includes counseling, library preparation (including single cell applications) and sequencing services.
Michael Rehli • Dept. Internal Medicine III • University Hospital
F.-J.-Strauss Allee 11 • 93053 Regensburg • Germany
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